Nicotinamide adenine dinucleotide (NAD+) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.
NMN and the incidence of Alzheimer’s disease, obesity and associated complications, cerebral and cardiac ischemia, and age- and diet-induced type 2 diabetes has been studied extensively . Though, previous attention of scientific community has been paid on NMN only as an intermediate in NAD+ biosynthesis, recently, a number of pharmacological activities triggered by increasing NAD+ levels in the body, especially anti-aging activity have been taken the center of attention. As a result, a number of studies including cell culture, animal models and human clinical trials have been conducted to investigate the promises and the safety concerns of using NMN as an anti-aging health product and the potential of using NMN as a supplement to avoid age-related disease conditions. Hence, this review intends to present the most recent advances and current knowledge on promises and safety concerns of the use of NMN as an anti-aging health product, its other pharmacological and therapeutic uses and mechanism of action underlying the anti-aging properties with an interest to stimulate further research and offer an insight to the possibility of translating successful preclinical and clinical anti-aging outcomes of NMN into an effective treatment of aging and age-related diseases.
Journal of Advanced Research, v0l 37 March 2022 pp267-268
Nicotinamide adenine dinucleotide (NAD+) levels in the body deplete with aging and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. However, NMN, as the precursor of NAD+, can slow down this process by elevating NAD+ levels in the body. A number of in vivo studies have indicated affirmative results of therapeutic effects for various age-induced complications with NMN supplementation. One preclinical and one clinical study have been conducted to investigate the safety concerns of NMN administration while a few more human clinical trials are being conducted. As there is a large influx of NMN based anti-aging products on the market, proper clinical investigations are urgently needed to find out the effectiveness and safety of NMN supplementation.
NMN and the incidence of Alzheimer’s disease, obesity and associated complications, cerebral and cardiac ischemia, and age- and diet-induced type 2 diabetes has been studied extensively . Though, previous attention of scientific community has been paid on NMN only as an intermediate in NAD+ biosynthesis, recently, a number of pharmacological activities triggered by increasing NAD+ levels in the body, especially anti-aging activity have been taken the center of attention. As a result, a number of studies including cell culture, animal models and human clinical trials have been conducted to investigate the promises and the safety concerns of using NMN as an anti-aging health product and the potential of using NMN as a supplement to avoid age-related disease conditions. Hence, this review intends to present the most recent advances and current knowledge on promises and safety concerns of the use of NMN as an anti-aging health product, its other pharmacological and therapeutic uses and mechanism of action underlying the anti-aging properties with an interest to stimulate further research and offer an insight to the possibility of translating successful preclinical and clinical anti-aging outcomes of NMN into an effective treatment of aging and age-related diseases.
Journal of Advanced Research, v0l 37 March 2022 pp267-268
